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385,386,387 Thus, by inhibiting PGAM5, AMPK suppresses necrosis, reduces ROS accumulation, and mitigates oxidative stress

PFL participated in the revision of the paper

Aging 3, 670687

This potentiating effect, comparable to that of chlorpromazine, a known inhibitor, suggests that the metabolites present in EEMC (probably alkaloids and/or flavonoids) act as efflux pump inhibitors (Coutinho et al., 2010)