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Graphical Abstract Keywords Hyperuricemia, Microbiota, Physical activity, Caveolae, Uric acid metabolism, Cardiovascular diseases, Metabolic syndrome Introduction Hyperuricemia (HU), a metabolic disorder characterized by elevated levels of uric acid (UA) in the bloodstream, is a significant global health concern

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After completion of the baseline MR scan, participants were randomly assigned in a ratio of 5:2 to either the intervention or control group using a computer-generated random-sequence allocation program

Several features enabled us to distinguish severe from moderate IPTB, for instance higher levels of total sulfur amino acids (AAs) ( P 0.05), and total glutathione-precursors ( P 0.03), as well as levels of individual methionine ( P 0.03), homocysteine ( P 0.002) (whereas the difference in cysteine was not significant, P 0.09), and serine ( P 0.04) in maternal blood at delivery, mainly in placebo arm