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Inflammation, a pathological process, is known to play an important role in heart disease and depression, resulting in tissue damage and disease exacerbation

This multi-receptor approach distinguishes it from existing licensed medicines such as semaglutide (Ozempic, Wegovy) or tirzepatide licensed in the UK as Mounjaro for type 2 diabetes and as Zepbound for obesity which act on fewer receptor pathways

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The heart-rate cost is mostly the glucagon arm: GLP-1 on its own nudges heart rate up a little and then flattens, while glucagon carries the part that keeps climbing with the dose