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Elevated metabolic danger signals, free fatty acids (FFAs), and the bacterial danger signal, LPS, activate the NF-B and MAPK pro-inflammatory pathways, which are regulators of systemic inflammation in obesity, by binding to TLRs (149), resulting in the transcription of pro-inflammatory cytokines, such as TNF-, IL-6, and IL-1, which initiate systemic inflammation (150)

Parallel studies in other organ systems have shown that integrating microbial composition with circulating metabolite profiles and host gene expression can reveal causal guthost pathways

10.3390/ijms22136871 157 ZhuL.HeC

The extraction process, separation, and identification of curcuminoids from turmeric Curcuma longa