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Integrated preclinical to first-in-human to indication-specific randomized clinical trials (RCTs) would be ideal candidates to combine mechanistic readouts (local drug/metabolite concentration, biofilm imaging, single-cell viability) with clinical readouts and, in advanced preclinical studies, local drug/metabolite concentrations

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Endocr Metab Immune Disord Drug Targets [Internet]

Oxidative stress is also reported to cause mitochondrial dysfunction which further leads to produce psychotic symptoms especially negative and cognitive symptoms

Software PsN (Perl Speaks NONMEM) v4.8.1 was used to access NONMEM v7.4.3 through Pirana v2.9.6 to perform modelling and simulation activities, while data management, data visualization and processing of modeling results were performed using R v4.2.1 with RStudio v2022.07.2 + 576