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Recent research has found that TRIM29 is downregulated in HCC tissue, potentially enhancing the activity of this pathway to promote the proliferation, invasion, and metastasis of HCC cells

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In connective tissues throughout the body, growth hormone and IGF-1 enhance the synthesis of collagen, elastin, and proteoglycans that provide structural support and mechanical properties essential for tissue function

This triggers a cascade that involves multiple immune cell types, signaling molecules, and feedback loops

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