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CYP3A5 Mediates Bioactivation and Cytotoxicity of Tetrandrine

For example, ZnT2 is strikingly overexpressed in luminal cells (T47D, poorly invasive) and luminal tumors, which could protect cells from zinc cytotoxicity by mobilizing zinc into intracellular vesicles 60

doi: 10.1038/s41419-022-05173-1 Summary Keywords ferroptosis, hepatocellular carcinoma, chemotherapy, drug resistance, therapy Citation Li X, Meng F, Wang H, Sun L, Chang S, Li G and Chen F (2024) Iron accumulation and lipid peroxidation: implication of ferroptosis in hepatocellular carcinoma