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Ames BN, McCann J, Yamasaki E

J Neuroinflam-mation

These bile acids act as signaling molecules that activate the FXR and the G protein-coupled bile acid receptor 1 (TGR5), pathways known to regulate lipid metabolism, promote cholesterol efflux, increase energy expenditure, and reduce hepatic steatosis and atherosclerotic risk (140, 145, 155, 156)