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These precursors stimulate the body to produce its own glutathione, providing a more sustainable way to boost levels

Environmental Pollution, 158 , 4854

Although structural insights into other FBXO22 native substrates are limited, our biochemical and cell-based data further support the notion that recruiting neosubstrates to the FBXO22 surface via degraders that engage Cys326 is unlikely to significantly perturb native substrate degradation

Alessio Fasanos research demonstrated that the protein zonulin regulates intestinal tight junctions, and that gliadin may increase intestinal permeability in genetically susceptible individuals, providing a mechanistic link between diet and autoimmune activation (Fasano, 2011)

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