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Thiamine hydrochloride (vitamin B1) in the formulation is known to cause life threatening anaphylaxis especially on multiple administrations if patient is allergic to it

Nutritional Deficiencies Beyond magnesium, deficiencies in vitamin D, B12, and potassium are established contributors to muscle cramping

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The action of sildenafil is to relax smooth muscles and dilate blood vessels by increasing levels of cyclic guanosine monophosphate, which is achieved by inhibiting phosphodiesterase type 5

With oral supplements, there can be sourcing and quality issues