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"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044

GHK-Cu (Copper Tripeptide-1) is a naturally occurring copper complex first identified in human plasma and later found in other body fluids such as saliva and urine

10.1016/j.jada.2005.02.005

Does not meaningfully raise IGF1 and shows a placebolike safety profile in human studies

Each compound has been studied on its own, but the combination has not been tested in any trial