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On the other hand, several studies proved that perinatal choline supplementation in Ts65Dn mice has beneficial effects on Ts65Dn offspring, including improvements in attention, emotion regulation, spatial memory, and the protection of cholinergic neurons in the medial septal nucleus (MSN) [107, 108, 111]

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Co-treatment with NAC led to a reduction in lipid peroxidation, nitric oxide (NO), and protein carbonyls, while maintaining levels of GSH, total antioxidant capacity, and antioxidant enzymes (GPx, GST, SOD, CAT)

doi: 10.1073/pnas.0605697103 7 DuX