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In agreement with these latter results, the work of Majors et al (1997) showed that a relatively low concentration of homocysteine (50 to 300 mol/L) stimulates collagen production in rabbit aortic smooth muscle cells that may favor extracellular matrix component accumulation in intimal lesions

136 The TGF- family of receptors comprises the type I receptor TGF-beta receptor (TR) I, the type II receptor (TRII), and the type III receptor (TRIII), among which TRI and TRII possess intrinsic kinase activity, which is essential for TGF- signaling

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The topic becomes much more relevant when symptoms last longer than expected, feel stronger over time, or appear alongside a more complicated medical picture