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The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium ( via the iProX partner repository 109,110 with the dataset identifier PXD059530

Targeting YAP activity and glutamine metabolism cooperatively suppresses tumor progression by preventing extracellular matrix accumulation

This can be explained by the difference in reaction rate between HOCl with methionine (which is relatively high) and the rate between HOCl with albumin (which is relatively low)

A recent study discovered a prodrug (JHU083) of the glutamine antagonist DON, which was designed to selectively become activated inside a tumor

To stabilize itself, it rapidly binds to another oxidized glutathione molecule, forming the disulfide compound GSSG