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Repurposing monoamine oxidase inhibitors (MAOI) for the treatment of rheumatoid arthritis possibly through modulating reactive oxidative stress mediated inflammatory cytokines

Globally, the burden of infertility has risen substantially, reaching 76.9% between 1990 and 2019 [4]

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doi: 10.1186/s13046-021-01983-x 158 KespohlMVachharajaniNLuuMHarbHPautzSWolffSet al

Panels show study design (a), higher plasma TMAO (b), worsened IPGTT (c), reduced insulin/C-peptide responses and GSIS under clamp (dk), pancreatic histology (l), altered islet composition by immunostaining (mo), and increased plasma glucagon (p), supporting a mechanistic link between TMAO and -cell dysfunction