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*Correspondence: Xueling Ye, [email protected] This article was submitted to Plant Genomics, a section of the journal Frontiers in Genetics Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The liberated active PROTAC then degrades STAT3, leading to the attenuation of CSC stemness and, notably, the reprogramming of the immunosuppressive TME toward an immune-supportive state

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