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Under irradiation, IGFBP-3 induces apoptosis and ROS production by activating NF-B signaling and ROS further promote IGFBP-3 mediated signaling activity

doi: 10.1111/jcmm.12399 33 WuHShengZ-QXieJLiRChenLLiG-Net al

Lactate then gets shuttled into neurons, and the reason why neurons like that is because it's thermodynamically favorable, much like beta-hydroxybutyrate which you mentioned, BHB, because it can shunt right into the TCA cycle in the mitochondria