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According to epidemiological studies, diets based on an abundance of flavonoids are relational with an increase in longevity and the reduction of cardiovascular disease incidence, and cancer risk [57]

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The unexpected slow clearance of metabolites M1, M2, and M16 in human was investigated in vitro and the experimental results suggested that an interplay between microbial reduction, reabsorption, and aldehyde oxidase (AO) oxidation (M2 M16 M2) could be a reason for an extended excretion profile