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5 Diagnosis Physicians typically consider COPD in patients with chronic cough, sputum production, shortness of breath, decreased exercise tolerance, and a history of exposure to tobacco smoke (GOLD 2011)

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For instance, Fanconi's syndrome is a hereditary or acquired condition in which the proximal tubular reabsorption function of the kidneys is impaired (37)

This is particularly the case with ion channel genes, in which most disease-predisposing variants in the literature are missense, non-P/LP, and likely disease predisposing versus disease causal (33)

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