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Nuclear translocation and transcription of antioxidant genes Upon dissociation, NRF2 translocates into the nucleus, where it binds to antioxidant response elements (AREs) located in the promoter regions of its target genes, thereby initiating their transcription

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However, the canonical ligand for TLR-4 is LPS, which is commonly found on cell walls of gram-negative bacteria (180) In LPS-driven models, LPS is either systemically administered or focally injected into the SN (181)

If we are in 2, we still have room to improve the conversion rate, but we need to make a more careful cost/benefit analysis of the work that needs to be done since the return on the investment starts to be lower as we make improvements

Its long history, certifications, and international OEM background reduce the uncertainty that many first-time founders feel