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The N-terminal amine, the histidine imidazole nitrogen, and an amide nitrogen of GHK together create a high-affinity coordination site for copper(II), which is why the apo-peptide readily forms the GHK-Cu complex

On the basis of the observation that GSH concentrations decrease as protein intake decreases from an adequate to a deficient level (10,14), it is reasonable to assume that the reduction in erythrocyte GSH synthesis represents a response to a restricted intracellular supply of the component amino acids

Mansour A, Romani M, Acharya AB, Rahman B, Verron E, Badran Z

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(2018) Surplus vitamin B(12) use does not reduce fatigue in patients with irritable bowel syndrome or inflammatory bowel disease: A randomized double-blind placebo-controlled trial