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In others, pathology is driven by the accumulation of toxic PUFA intermediates or incompletely metabolized LC and VLC-PUFAs within the RPE, leading to cellular stress, including ER stress, oxidative stress and subsequently cell death

Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine beta-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial

Construction of microbial consortia for microbial degradation of complex compounds

Modern double-blind RCT, older human study, or mechanistic extrapolation

Watanabe K, Shoja MM, Loukas M, Tubbs RS