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Importantly, multiple independent studies have observed that pro-inflammatory cytokines can induce behavioral deficits, mood disorders, and cognitive impairments via monoamine and acetylcholine dysfunction, glutamate elevation, neuroendocrine activation, and impaired neuroplasticity [15, 26]

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Notably, models trained with both MAGs and isolates performed significantly better (two-sided Wilcoxon rank-sum test, P 0.5% to any known isolate

J Clin Microbiol

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: a randomized, double-blind controlled clinical trial