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Dose escalation phase (titration) After the first 4 weeks, if the medication is well tolerated, your healthcare provider will typically increase the dosage to 5 mg once weekly for the next 4 weeks (weeks 5-8)

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doi: 10.3390/pharmaceutics15102439

All of the pieces that I feel like being able to explain why someones back hurts to them and the mechanisms of whats going on in the structures that are affected is really, really, really important when youre trying to help someone not be fearful of moving when their back is still bothering them