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Proc Natl Acad Sci U S A 98(1):2716 Singh A, Rosenthal PJ (2001) Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum

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Understanding the mechanisms of ADA generation and the major factors that influence immunogenicity of mAbs will help us design safer mAbs with lower drug rejection rates

This raises an important questionwhat is the advantage of opting to use selenium when sulfur is structurally similar and requires fewer complex mechanisms to be utilized