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Tumor-infiltrating Treg cells also play a critical role by sustaining angiogenesis directly through VEGF secretion and supporting endothelial cell recruitment and expansion 83,87

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UVA and UVB both play a role in photoaging, although UVA rays have longer wavelengths because UVA-1 rays (340-400 nm) can be absorbed deeply into the human skin and exert effects directly through the dermal fibroblast level (13)