Symptoms Checklist Vitamin B12 Deficiency: Persistent fatigue and weakness often the first and most prominent symptom Shortness of breath and dizziness from anemia and impaired oxygen delivery Pale or yellowish skin from red blood cell breakdown Rapid or irregular heartbeat from anemia-related cardiac compensation Tingling or pins-and-needles sensation in hands, feet, or legs neurological symptom Numbness in the extremities progressive nerve damage Muscle weakness and difficulty walking or maintaining balance Memory problems and difficulty concentrating Brain fog and mental confusion Depression, anxiety, and mood changes Irritability Glossitis a swollen, inflamed, and smooth (rather than bumpy) tongue Mouth ulcers Headaches Vision disturbances In severe cases: spinal cord degeneration (subacute combined degeneration) causing serious neurological disability It is important to note that neurological symptoms from B12 deficiency can occur even when blood cell changes (anemia) are absent particularly in people taking folate supplements, which can mask the blood picture of B12 deficiency while nerve damage continues to progress
Because steroids can have systemic effects with repeated use, many clinicians reserve them for specific situations
Moreover, the PGC-1/ERR axis directly promotes the expression of key fusion and fission genes
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Wang J, Liu K, Xing R, Yan X
