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Similarly, in Ke's research, a multifunctional bioreactor for starvation-chemotherapy was constructed by embedding glucose oxidase (GOx) and DOX in metalorganic framework nanoparticles modified by targeting ligands (RGD) (referred to as RGD-mGZD) (Ke et al

By analogy with findings in other cell types, MAMs may potentiate the activity of Ca 2+ -dependent enzymes in the TCA cycle by regulating Ca 2+ transfer between the endoplasmic reticulum and mitochondria, thereby potentially enhancing mitochondrial OXPHOS efficiency and ATP production.However, direct evidence supporting this mechanism in ovarian cells is currently lacking