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Science (2020) 368(6487):eaaw5473

Macip, A second generation of senotherapies: the development of targeted senolytics, senoblockers and senoreversers for healthy ageing

Our findings suggest that irisin activates the SIRT1 signaling pathway, which is not exclusive to dopaminergic neurons and may also modulate glial function, as evidenced by reduced microglial activation