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In the early phase, within the first week of treatment, oligodendrocyte death can be observed as early as two days after treatment begins

Production of transcriptomics data set by RNA-Seq

167 However, the antioxidant properties of AAT remain largely unknown

Abbreviations ABCA1: ATP-binding cassette transporter A1 ABCG1: ATP Binding Cassette Subfamily G Member 1 ACAT1/SOAT1: Acetyl-CoA Acetyltransferase EGFR: Epidermal Growth Factor Receptor ER: Estrogen Receptor HDL: high density lipoprotein HER2: Human Epidermal Growth Factor 2 HGSC: High-Grade Serous Carcinoma HMGCR: HMG-CoA reductase INSIG: Insulin-induced gene protein LAMP-1: Lysosomal Associated Membrane Protein 1 LAMP-2: Lysosomal Associated Membrane Protein 2 LIMP-2/SCARBB2: Lysosomal Integral Membrane Protein 2/Scavenger Receptor Class B Member 2 LDL: low density lipoprotein LDLR: Low density lipoprotein receptor LXR: Liver X receptor MAPK: Mitogen Activated Protein Kinase mTOR: Mammalian Target of Rapamycin MZF1: Myeloid Zinc Finger-1 NPC1 and NPC2: Niemann-Pick type C protein 1 and 2 PI3K: Phosphoinositide 3 kinases PCSK9: Proprotein convertase subtilisin/kexin type 9 PTEN: Phosphatase and Tensin Homolog SCAP: SREBP-2 cleavage activation protein SR-B1: SCARBB1

DPPOS Study Design The DPPOS follow-up study started in 2002