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Bacterial amyloid could spread to the brain in a prion-like fashion and contribute to aggregate formation, in addition to triggering further amyloid production by neuronal proteins (66)

The cortex and hippocampus, two parts of the brain involved in learning and memory, both contain serotonin receptors (Meneses 1999)

13 , 655672, doi:10.1038/nrd4363 (2014)

Hydroxocobalamin is a form of vitamin B12 that replaces the insufficient amounts in your body when you have a deficiency, often caused by conditions like pernicious anaemia

Alternatively, future studies could integrate patient-derived tumor tissues with immune cells (e.g., PDX models) to evaluate the synergistic effects of ferroptosis inducers (such as RSL3) with immune checkpoint inhibitors, as well as establish tumor organoid-immune cell (e.g., CAR-T) co-culture systems to quantitatively assess the impact of ferroptosis on immune cell infiltration and cytotoxic function