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Treating ICB-resistant cancer by inhibiting PD-L1 via DHHC3 degradation induced by cell penetrating peptide-induced chimera conjugates

Fukui, Y., Kato, M., Inoue, Y., Matsubara, A

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Conservative dosing approach (GI-sensitive individuals) For those who need gentler escalation

By activating the VDR signaling pathway, these probiotics ultimately promote vitamin D absorption and the expression of its target genes, such as the antimicrobial peptide cathelicidin, thereby exerting anti-inflammatory effects (Wu et al., 2015)