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Tufts Center for the Study of Drug Development

This is highly speculative because: Oral bioavailability differs between species Route of administration affects systemic exposure Species differences in peptide metabolism and clearance are unknown Current Practice Patterns Current practice patterns from unregulated sources typically involve: Subcutaneous injection: 0.25-0.5 mg once or twice daily, administered near injection sites for localized effects or abdominally for systemic distribution

Burton JP, Wescombe PA, Macklaim JM, Chai MHC, MacDonald K, Hale JDF, Tagg JR, Reid G, Gloor GB, Cadieux PA (2013) Persistence of the oral probiotic Streptococcus salivarius M18 is dose dependent and megaplasmid transfer can augment their bacteriocin production and adhesion characteristics