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Plant Physiol 128:970977 Mullineaux P, Karpinski S (2002) Signal transduction in response to excess light: getting out of the chloroplast

Period proteins PER13 and Cryptochrome ones CRY12 form complexes, and translocate to the nucleus to inhibit CLOCK-BMAL1 activity, thus closing the negative feedback loop

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Given the promising results in animal studies, clinical studies are required to evaluate the effect of sulforaphane on neurological outcomes in humans

PBM shows promise for treating chronic TBI in a degenerative state, particularly for suspected CTE