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10.1152/ajpcell.00422.2011 52 ChokshiR.MatsushitaM.KozakJ

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280 Furthermore, activation of the inflammation-related NLRP3 inflammasome signaling pathway in different types of neural cells was closely associated with high cholesterol load, which triggered neuroprotective properties in activated microglia but promoted oxidative stress in neurons, further enhancing the expression of NLRP3 inflammasomes, inducing neuronal pyroptosis, and impairing the phagocytic capacity of microglia

As a result, tiered health plan structures are typically reserved for non-HDHP alternatives

Meng T, et al