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Ascorbate peroxidase-related (APx-R) is a new heme-containing protein functionally associated with ascorbate peroxidase but evolutionarily divergent

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The exclusion criteria were BMI 30, HIV-positive status, irregular menstrual cycle, pregnancy or breastfeeding in the past 6 months, COC/hormone use in the past 4 years (controls), use of COC formulations other than DRSP/EE, use of COC for less than 3 months, self-reported indications of diabetes, liver or kidney disease, asthma, other chronic diseases, chronic medication use, and smoking more than 5 cigarettes/day

Unlike an additive effect (1+1=2), synergy produces a result of the type 1+1=3

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