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The honest summary is that long-term human safety data is missing and the angiogenesis mechanism is an unresolved theoretical concern

Sikiric et al., 2020b) than the generally established angiogenic growth factors, epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) (Tarnawski and Ahluwalia, 2012