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These compounds may serve as scaffolds for drug development and as adjuncts in multimodal regimens

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96 DMT1 inhibitors such as ebselen, 126 pyrrolidine dithiocarbamate (PDTC), 126 and benzylisothiourea 127 have been shown to reduce iron-induced damage by potently reducing the DMT1-mediated cellular uptake of NTBI, indicating that DMT1 may be a promising target for regulating ferroptosis to manage ferroptosis-related diseases

PMID: 23423860