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To evaluate the actual importance of the individual metabolites, the spectral regions highlighted in the S-line plot were quantified by Chenomx NMR Suite 7.1

Another antagonist of MC1R, undecylenoyl phenylalanine, also induced significant lightening of pigmented lesions when applied twice daily at 2% in patients with melasma or SL [118, 119]

Similarly, it reduced the levels of the GSH (Figure 3C) and the TAC (Figure 3D) in brain cell homogenates and increased the ratio GSSG/GSH (Figure 3E)

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