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Engineering the Provitamin A (-Carotene) Biosynthetic Pathway into (Carotenoid-Free) Rice Endosperm

Schaeffer EM, Srinivas S, Adra N, An Y, Bitting R, Chapin B, et al

The pathogenetic mechanisms underlying this syndrome include disruption of hunger/satiety centers (damage to arcuate, ventromedial, and paraventricular hypothalamic nuclei), leptin resistance despite elevated circulating leptin levels, autonomic dysregulation with reduced energy expenditure, hypothalamic-pituitary axis dysfunction, and local inflammatory processes [87, 88]

doi: 10.1523/JNEUROSCI.21-19-07742.2001 29 YamaguchiYOkadaKMizunoTOtaTYamadaHDoiMet al

In some cases, a person might carry two MTHFR mutations, in which case, their body is only able to detox at a rate of 10% compared to that of someone without the mutation