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It is worth noting that the derivation of HBGVs applies extrapolation factors (also termed safety factors) to account for toxicodynamic and toxicokinetic differences between species and inter-individual variability in humans

doi: 10.1007/s00204-023-03562-9 12 JuchnowiczDDzikowskiMRogJWaszkiewiczNZalewskaAMaciejczykMet al

Furthermore, rodents do not easily develop addictive behaviour, naturally decrease alcohol consumption as acetaldehyde levels rise, metabolize alcohol quickly, have a high basal metabolic rate and demonstrate certain differences in the innate immune system 140

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Stress and the Adrenal Connection When we are stressed, our bodies use up amino acids at a much faster rate