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Studies indicate that exposure to PS-NPs significantly downregulates dopamine levels in zebrafish (Ren et al., 2024), mechanistically linked to MPs-triggered neuroinflammation that inhibits tyrosine hydroxylase, a key enzyme in dopamine synthesis (Wang et al., 2025)

TB-500 is not FDA approved for any therapeutic indication

Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification

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