glutathione biosynthesis genes REGULATION OF SYNTHESIS Biosynthesis pathway of glutathione (GSH)

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Some studies [55, 56, 57] showed that each catalase tetramer has four tightly bound NADPH molecules that appear to be important only to protect the enzyme against inactivation by its own substrate (H 2 O 2 ), and are not essential for its catalytic activity

Elevated intracellular GSH levels represent both a barrier to conventional therapies and an opportunity to design redox-responsive drug delivery systems

As with Keshan disease, KBD is prevalent in selenium-deficient provinces and thus generally affects people with very low selenium intakes (58, 59)

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