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10.1016/j.intimp.2022.108983 2 AbusharkhF

Levi M, van der Poll T

: Glutathione (GSH) is synthesized in the cytoplasm in virtually all cells from its constituent amino acids by two sequential ATP-requiring enzyme-catalyzed reactions (see figure below) [1]

Additionally, 3-MST, in conjunction with CAT, generates H 2 S from L-cysteine in both the cytoplasm and mitochondria

By combining machine learning (such as Bayesian inference modeling) and computational tools (such as PharmMapper and DRAR-CPI), we can efficiently process large-scale compound-target data, predict potential targets, and screen key proteins (such as mitogen-activated protein kinase 14 (MAPK14)), and identify candidate molecules with therapeutic potential