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Physical Symptoms Physical symptoms of a B12 deficiency can include a swollen, inflamed tongue, mouth ulcers, and vision disturbances

Step 1: Start with a lower dose

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

10.1038/nrrheum.2015.13 68 SakaiD.MochidaJ.IwashinaT.HiyamaA.OmiH.ImaiM.et al (2006)

Cells were transfected at 5060% confluency with 50 ng of pCMV-HA-LMP1 plasmids and 100 ng of pRK5-Flag-TRAF6 plasmids, adjusted to a total of 500 ng DNA per sample with pRK5 empty vector, using Lipofectamine 2000 (Thermo Fisher Scientific) according to the manufacturers instructions