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The significant increase in AML blast cells leads to higher glucose uptake and the accumulation of a large amount of lactate, even under unlimited oxygen conditions, noted as the Warburg effect (131)

KCa3.1, Calcium-activated Potassium Channel 3.1

V.GomesP

An interesting example of this regulation was found in human glioma cells where stimulation with HGF increased the expression levels of VEGF and tumor-associated angiogenesis