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Cancer Cell 16 (5), 425438

1 Introduction Myelodysplastic neoplasms (MDS) are a group of clonal myeloid stem and progenitor cell disorders, characterized by bone marrow (BM) failure resulting in cytopenias and a propensity to progress to acute myeloid leukemia (AML) ( Monocytes fulfill a crucial role in the immune system and their presence in MDS has been correlated to leukemic transformation ( To date, reviews on TM expression comprise mostly endothelial-TM ( 2 Monocyte biology in healthy, aging individuals 2.1 Monocyte ontogeny, subsets, and heterogeneity Monocytes are named after their morphology: cells with a single nucleus

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Blood 59(2):216-25, 1982

(2008) SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism