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However, negative symptoms and cognitive impairments are virtually irresponsive to typical antipsychotics because they involve other neurotransmission systems, namely those operated by glutamate and -aminobutyric acid (GABA), and are furthermore caused by a neurodegenerative process (discussed in [2, 3])

The primary pathway involves its rapid reaction with superoxide radicals (O 2 ) to form peroxynitrite (ONOO), a highly potent and damaging oxidant

Chronic cases may require a full 12-week cycle and occasionally a second cycle after a break to reach the target endpoint

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No positive correlation was found between the general health condition of the patients (ASA Classification), gender, age, BMI (body mass index) values and the oxidative stress markers