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In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases

Front Immunol 13:1009742 Xue X, Wang M, Cui J et al (2025) Glutathione metabolism in ferroptosis and cancer therapy

They reported that macrophages exposed to ferrylHb in atherosclerotic plaques exhibited a distinct transcriptomic profile affecting gene expressions associated with inflammation (IL-1 and TNF- et), angiogenesis, tissue remodeling, iron metabolism, apoptosis, PI3K signaling, lipid transport, and calcification, thereby contributing to the transformation of atherosclerotic lesions toward aproatherogenic phenotype (Potor et al., 2021)

Cardiolipin externalization activates mitophagy, and this is essential for rapidly sequestering injured mitochondria for clearance in the autophagosomes (Kagan et al., 2016)

Buffone MG, Wertheimer EV, Visconti PE, Krapf D