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This theory is further supported by the presence of Lewy bodies in the ENS even before their appearance in other areas of the body, including the CNS [117]

[229]. J.R

2.2 In vivo models In the last 30 years numerous animal models for CF have been developed for research purposes

The main mechanisms are the epithelial barrier development, the intestinal mucosa adhesion progression, the immune system modulation, the antibacterial substances production, the bacterial adhesion simultaneous suppression, and the pathogen competitive exclusion [7]